CON-CRĒT® Creatine HCl + Nitric Oxide

Creatine is nitrogenous organic acid which naturally occurs in vertebrates and helps to supply energy to muscle and all cells of the body.  It’s a compound that’s involved in the formation of adenosine triphosphate (ATP) – the body’s universal energy molecule.  Creatine is made in the liver of the human body but is produced to fulfill only approximately half of the daily creatine required by the body.  It is biosynthesized from three different amino acids - arginine, glycine, and methionine. The balance of required creatine is taken in by nutritional food sources in the daily diet, mainly from meat (although much of it is destroyed by cooking).  Approximately 95% of the body’s creatine ends up being stored in the skeletal muscles, and the remaining 5% is found in brain, heart, testes, inner ear, hair cells and other organs and cells.  Once it's used in the formation of ATP, creatine is converted to creatinine and is excreted by the body. 

When you consume food, your body absorbs the nutrients like glucose to provide fuel for your cells to operate. When your body absorbs glucose, it undergoes glycolysis to convert the glucose to cellular fuel in order to energize your body. Following glycolysis, your body begins the Krebs cycle (also known as the citric acid cycle), which serves as the main source of energy for your cells.  The Krebs Cycle produces many molecules for your body but one of the most significant of these molecules is ATP (Adenosine triphosphate) which is the body’s universal energy molecule used to power all cells. Once ATP is used/burned by the cells, the bi-products are ADP (Adenosine diphosphate) and a loose phosphate. In order to “recycle” the ATP and thereby further energize your body’s cells (because the Krebs Cycle can’t make more ATP fast enough), creatine molecules pick up the loose phosphates and reattach them to ADP to quickly regenerate ATP, thus providing your cells with additional energy.

Yes. Creatine has countless benefits for your entire body as the molecule works to energize all your body’s cells. It is absolutely needed and used by every cell in the body!  Creatine helps support your immune system, improve brain function, and provide a stimulant free energy source for your whole body. 

CON-CRĒT® Patented Creatine HCl is the #1 bioavailable creatine with 59X greater solubility and 70% greater plasma uptake than standard creatine (see below).  Backed by 8 US Patents, CON-CRĒT® is also the only micro-dosing creatine and is thereby able to avoid any of the unpleasant side effects normally caused by other forms of creatine. Because CON-CRĒT® is concentrated creatine, there is no bloating, water retention, cramping or other digestive issues when used as directed. 

CON-CRĒT® has proven to be the most soluble and potent creatine on the market and was proven in multiple academic studies to be at least 59X more soluble* than creatine monohydrate.  This is significant because creatines vary in performance largely based on solubility. And the reason solubility is crucial is that when you increase creatine solubility (the ability to dissolve), you enhance creatine delivery (absorption into body and ultimately into the muscles). 

Solubility is important – while there are significant studies that examine the percentage of water in the human body, it is widely agreed that the typical male has approximately 69% of their body mass comprised of water. For females, this number is approximately 55% (due to the higher proportion of body fat). Obviously, water is a critical component of life, and instrumental in maintaining health and wellness.  These facts point to the significance of CON-CRĒT being soluble and stable in water.

The essence of solubility importance lies in the fact that for creatine to be absorbed into the bloodstream and penetrate the muscles, it must be soluble.  Solubility is a critical factor in the absorption of creatine and its efficacy.

As referenced above, this also ends up being related to bioavailability and plasma uptake.  The findings of research conducted with two major universities and performed by testing blood plasma in human subjects after oral dosing were presented at the ISSN Conference in June 2009.  The results of this second study showed convincing evidence of a significant improvement in plasma uptake with creatine hydrochloride.  In the study, CON-CRĒT demonstrated up to 70% increase** in plasma uptake compared to creatine monohydrate (CM).  These results reinforced the notion that CON-CRĒT is the most readily absorbed creatine form available.  This fact is the reason that CON-CRET does not require loading of large initial doses or cycling on and off the supplement.  CON-CRET is available in powder and capsule forms, and each serving of CON-CRĒT is equivalent to the potency of over 3 – 5 grams of creatine monohydrate.  

* CON-CRĒT has repeatedly shown to have at least 59X greater aqueous solubility than creatine monohydrate when stirred for 2 minutes or less (See website for study summary.  Research on file.)

** CON-CRĒT was shown in this double blind, placebo-controlled, balanced crossover study to have an FDA bioequivalence of up to 70% greater plasma uptake when assessing area under curve (AUC) calculations at various time intervals post dosing (See website for study summary.  Research on file.)

No.  Because CON-CRĒT® Creatine HCl is concentrated creatine and has far superior uptake to other forms of creatine, there is no need to load or cycle the product.  You simply use it according to directions for improved performance and health. 

Due to its superior bioavailability and rapid absorption, individuals can see and feel the benefits of creatine in as little as 1-3 workouts.