Creatine powder displayed in laboratory glassware

CREATINE 101:

What it is, how it works, & why form matters.

Creatine does more than support workouts. Learn how it helps recycle cellular energy, what benefits it may provide, and why CON-CRĒT Creatine HCl offers a simpler way to supplement.

Learn how creatine helps recycle cellular energy, what benefits it may provide, and why CON-CRĒT Creatine HCl offers a simpler way to supplement.

BEYOND THE GYM

WHAT ARE THE BENEFITS OF CREATINE?

Creatine helps recycle energy in cells throughout the body. That is why its potential benefits extend from physical performance to cognition and healthy aging.

MUSCLE & STRENGTH

Supports strength, power and lean muscle by helping muscles rapidly recycle cellular energy.*

Your muscles rely on ATP for the energy used during lifting, sprinting and other high-intensity activity. Because that supply is used quickly, creatine helps convert ADP back into usable ATP. This supports repeated efforts, strength, power and the development of lean muscle when paired with consistent resistance training.*

EXERCISE & RECOVERY

Helps replenish cellular energy to support demanding activity and recovery afterward.*

Intense exercise rapidly uses the energy stored in working muscles. The creatine-phosphocreatine system helps restore that energy between repeated bursts of activity and replenishes your muscles’ energy supply after training. This supports exercise performance, endurance and post-workout recovery.*

BRAIN & COGNITION

Supports cellular energy in the brain for focus, memory and mental performance.*

Your brain has significant energy demands and relies on ATP to perform at its best. Creatine helps support ATP regeneration in brain cells, providing cellular energy for focus, memory, concentration and clear thinking. Emerging research continues to examine creatine’s cognitive benefits, particularly during periods of increased mental demand.*

HEALTHY AGING

Supports the cellular energy and muscle function that help you stay strong and active as you age.*

Maintaining strength, lean muscle and physical function becomes increasingly important with age. By supporting cellular energy availability, creatine can help preserve the capacity needed to stay active and perform everyday activities. Researchers are also continuing to study creatine’s potential role in cognitive function and overall healthy aging.*

IMMUNE SUPPORT

Supports the cellular energy T cells need to maintain a healthy immune response.*

T cells are an important part of the body’s adaptive immune system, and responding to a challenge requires considerable cellular energy. Early research suggests that creatine uptake and creatine kinase activity help support CD8+ T-cell maintenance, activation and function. By acting as a cellular energy buffer, creatine may help immune cells access and recycle the energy needed to support a healthy immune response.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

CREATINE, EVOLVED

MONOHYDRATE BUILT THE CATEGORY. CREATINE HCl IMPROVED THE EXPERIENCE.

Creatine monohydrate established the category and remains its most extensively studied form. Creatine HCl was developed to deliver creatine in a markedly more water-soluble format designed for an easier daily routine.

CREATINE MONOHYDRATE

THE CATEGORY STANDARD

CREATINE MONOHYDRATE

The most extensively studied form of creatine and the foundation of the category.

  • Extensively studied
  • Category standard
  • Multi-gram format
CREATINE HCl

ENGINEERED FOR THE ROUTINE

CREATINE HCl

Creatine paired with hydrochloric acid to create a markedly more water-soluble form.

  • Highly water-soluble
  • Compact serving
  • Easy daily routine

THE DIFFERENCE IS IN THE FORM

Tap any topic on mobile to compare both forms.

TOPIC
CREATINE MONOHYDRATE
CREATINE HCl
WHAT IT IS
Creatine crystallized with one molecule of water.
Creatine paired with hydrochloric acid to form a salt.
WATER SOLUBILITY
Less soluble in water.
Approximately 38× more water-soluble under the conditions of one peer-reviewed laboratory study.
RESEARCH HISTORY
The most extensively studied form of creatine.
A newer form with a smaller but growing body of form-specific research.
DAILY FORMAT
Commonly offered in multi-gram servings.
CON-CRĒT uses a compact labeled serving.
PERFORMANCE EVIDENCE
Extensively studied for strength and high-intensity performance.
Delivers creatine, but current research does not establish superior strength or muscle gains over monohydrate.
WHAT IT ISHow each creatine form is made.
CREATINE MONOHYDRATE
Creatine crystallized with one molecule of water.
CREATINE HCl
Creatine paired with hydrochloric acid to form a salt.
WATER SOLUBILITYHow readily each form dissolves in water.
CREATINE MONOHYDRATE
Less soluble in water.
CREATINE HCl
Approximately 38× more water-soluble under the conditions of one peer-reviewed laboratory study.
RESEARCH HISTORYThe depth of form-specific research.
CREATINE MONOHYDRATE
The most extensively studied form of creatine.
CREATINE HCl
A newer form with a smaller but growing body of form-specific research.
DAILY FORMATHow each form commonly fits into a daily routine.
CREATINE MONOHYDRATE
Commonly offered in multi-gram servings.
CREATINE HCl
CON-CRĒT uses a compact labeled serving.
PERFORMANCE EVIDENCEWhat current research can support.
CREATINE MONOHYDRATE
Extensively studied for strength and high-intensity performance.
CREATINE HCl
Delivers creatine, but current research does not establish superior strength or muscle gains over monohydrate.
MARKEDLY MORE WATER-SOLUBLE

38×

MARKEDLY MORE WATER-SOLUBLE

In a peer-reviewed laboratory study, creatine HCl demonstrated approximately 38× greater aqueous solubility than creatine monohydrate under the study’s test conditions.

Solubility results vary based on temperature, pH, testing method and the monohydrate preparation evaluated. Greater solubility does not necessarily mean greater strength or muscle-building results.

CREATINE WAS ALREADY PROVEN. WE FOCUSED ON THE EXPERIENCE.

CON-CRĒT uses Creatine HCl because its markedly greater water solubility allows us to formulate creatine in a compact, easy-to-mix format built for consistent daily use.

SHOP CON-CRĒT
CREATINE WAS ALREADY PROVEN. WE FOCUSED ON THE EXPERIENCE.

Source: Gufford et al. (2010). The 38× figure reflects aqueous solubility measured at 25°C in one laboratory study; results may vary with test conditions.

EXPLORE THE RESEARCH →