RESEARCH HIGHLIGHTS

AN ONGOING COMMITMENT TO RESEARCH

CON-CRĒT continues to support research that expands scientific understanding of Creatine HCl, from how it is absorbed to its potential applications across brain health, healthy aging and performance.

A stylized blue brain illustration with glowing synaptic connections on a light gray background.

PRECLINICAL RESEARCH

2026

NEW RESEARCH SUGGESTS CREATINE HCl MAY HELP LESSEN CONCUSSIONS

A new preclinical study examined how CON-CRĒT® Creatine HCl supplementation before and after traumatic brain injury affected the brain’s response to injury. Researchers observed encouraging, sex-dependent effects involving neuroinflammation, neuronal survival and inhibitory synaptic remodeling.

This research studied Creatine HCl, and its findings cannot be generalized to other forms of creatine.

NEUROINFLAMMATION NEURONAL SURVIVAL SYNAPTIC REMODELING
VIEW STUDY

HUMAN CLINICAL TRIAL

2025

CREATINE HCl AND COGNITION DURING MENOPAUSE

In a randomized, placebo-controlled trial, low-dose Creatine HCl supplementation increased brain creatine concentrations and improved several measures of cognitive performance in perimenopausal and menopausal women.

VIEW STUDY

SCIENTIFIC REVIEW

2013

UNDERSTANDING CREATINE ABSORPTION

This scientific review examines the mechanisms governing creatine absorption and compares creatine formulations, including evidence that greater aqueous solubility may support more efficient oral absorption.

VIEW STUDY

PRECLINICAL RESEARCH

2018

CREATINE MONOHYDRATE BIOAVAILABILITY: DEBUNKING A MYTH

This pharmacokinetic study found that creatine monohydrate absorption in rats was dose-dependent and less than complete. Modeling predicted greater oral bioavailability for the more soluble Creatine HCl formulation.

VIEW STUDY