The brain runs on energy
Creatine helps cells recycle the energy they need to function—including cells in the brain.
THE HIT IS ONLY THE BEGINNING.
New Research on Creatine HCl and Traumatic Brain Injury
New research data suggests that Creatine HCl may influence the brain’s response to a concussion and lessen damage.*
A new study examined how CON-CRĒT® Creatine HCl influenced key biological responses after brain injury.*
A new study examined how CON-CRĒT® Creatine HCl influenced key biological signs before and after a controlled brain injury.
THE BIG IDEA
WHY THIS RESEARCH MATTERS
The major harmful effects of concussions and traumatic brain injury (TBI) are the damage they cause to brain cells, but also the brain inflammation that happens after the head trauma.
The effects of an injury continue after impact
A traumatic injury can trigger ongoing cellular stress and inflammation after the initial hit.
Researchers are exploring creatine’s potential role
This study investigated how Creatine HCl affected key biological signs before and after injury.
THE BRAIN RUNS ON ENERGY.
The brain relies on a steady supply of cellular energy to think, communicate, and respond to stress. After a traumatic injury, normal energy processes can be disrupted—just as the brain is working to restore balance.
Creatine helps cells regenerate ATP, the energy they use to function. That connection is why researchers are exploring how Creatine HCl may influence the brain’s biological response before and after injury.*
A CLOSER LOOK
WHAT DID THE STUDY EXAMINE?
Researchers used a controlled preclinical model to explore how Creatine HCl might influence the brain’s biological response before and after a traumatic injury.
Before injury
Creatine HCl was provided before a controlled traumatic brain injury.
After injury
Supplementation continued after the injury so researchers could observe the brain’s response.
What researchers measured
Researchers examined signs involving inflammation, brain-cell survival, and communication between brain cells.
See the study design at a glance
The study used a controlled preclinical model and evaluated male and female subjects. CON-CRĒT Creatine HCl was provided before and after injury. Full methodology, dosing, researcher, funding, and publication details can be added here as they become available.
PRECLINICAL RESEARCH
WHAT RESEARCHERS OBSERVED
ENCOURAGING FINDINGS
The study revealed several profound observations.
FINDING 01
Less inflammation
Researchers observed lower signs of brain inflammation following Creatine HCl supplementation.*
FINDING 02
Signs of greater brain-cell survival
The findings included encouraging differences in the survival of brain cells (neurons) following Creatine HCl supplementation.*
FINDING 03
Changes in brain-cell communication
Researchers also observed encouraging differences in how important connections (synapses) were protected after injury.*
FINDING 04
Male and female responses were not always the same
Some findings varied between male and female subjects, but both experienced improved outcomes and less brain cell damage with Creatine HCl supplementation.*
MEET CON-CRĒT
THE ORIGINAL CREATINE HCl
CON-CRĒT created the Original Creatine HCl to make daily creatine simpler. Its markedly greater water solubility allows for a compact, easy-to-mix format designed for consistent daily use.
Today, CON-CRĒT continues to support research exploring creatine’s potential across muscle, cognition, healthy aging, and whole-body wellness.
Original Creatine HCl since 2002
Made in the USA
NSF Certified for Sport® options
Built for daily use
QUESTIONS, ANSWERED
WHAT TO KNOW ABOUT THIS RESEARCH
Quick answers about the study, what it found, and what researchers still need to learn.
Was this study conducted in people?No—this was preclinical research.
No. This was preclinical research. Additional studies would be needed to determine whether similar effects occur in humans.
Does this mean CON-CRĒT prevents concussions?No. This research does not establish prevention or treatment.*
No. CON-CRĒT is not intended to prevent, diagnose, treat, or cure concussion or traumatic brain injury.*
Why are researchers studying creatine and the brain?Creatine helps cells recycle energy.
Creatine helps cells recycle energy. Because the brain has high and changing energy demands, researchers are studying how creatine may support several aspects of brain function and health.
What form of creatine was studied?The researchers studied CON-CRĒT Creatine HCl.
The researchers studied CON-CRĒT Creatine HCl. The findings should not automatically be generalized to other forms of creatine.*
Where can I read the complete study?The publication will be linked when available.
The complete publication will be linked here when available. You can also explore CON-CRĒT’s current research library.
EXPLORE THE RESEARCHStudy details and sources
Add the study title, authors, institution, journal or publication status, funding disclosure, and full citation here when those details are ready.
This page discusses emerging preclinical research—not a human clinical trial—and is provided for educational purposes. CON-CRĒT is not intended to diagnose, treat, cure, or prevent traumatic brain injury or any disease. Anyone with a suspected concussion or brain injury should seek evaluation from a qualified healthcare provider. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.